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Is it ok to stop taking Metoprolol 50mg and start taking Amlodipine 10 mg.? My doctor has switched my High Blood pressure med from Metoprolol to amlodipine. I had read that that you had to slowly reduce Metoprolol but he did not tell me to. Anybody had a similar experience.

tinahdez@sbcglobal.net replied: "My brother stopped taking his Metoprolol and he fainted and had to go to the ER. Do not stop suddenly. Instead, reduce the dosage to 25 mg for a few days, then to half of that for another few days, then skip a day a few times, then you can stop. I take it too, and it makes me dizzy so I take 12.5 mg twice a day with meals. Even that relaxes me a lot and my pulse is always 60."

A mom replied: "Do not suddenly stop taking Metoprolol. Talk to your doctor or pharmacist before reducing or stopping this medication. "...abruptly stopping metoprolol can suddenly worsen angina, and occasionally precipitate heart attacks. If it is necessary to discontinue metoprolol, its dosage should be reduced gradually over several weeks. " "do not stop using this drug without first consulting your doctor. Your condition may become worse when the drug is suddenly stopped. If your doctor decides you should no longer use this drug, you must gradually decrease your dose according to your doctor's instructions. When gradually stopping this medication, it is recommended that you temporarily limit physical activity to decrease the work on the heart. Seek immediate medical attention if you develop: worsening chest pain, tightness or pressure in the chest, chest pain spreading to the jaw/neck/arm, sweating, trouble breathing or fast/irregular heartbeat.""

i suffer from high blood pressure and take atenonol 50mg/amlodipine 10 mg and have the usual side effects? i have recently read amlodipine is banned in belgium and holland but cannot find any information why can anyone help

funny_cat25 replied: "http://www.webmd.com/drugs/drug-5891-Amlodipine.aspx?drugid=5891&drugname=Amlodipine&pagenumber=6 "

John K replied: "Hello, I used to sell amlodipine (TM Norvasc) so this answer may be a little stilted. One comment about the sites the other answerer sent you to, they're good, but keep in mind when the WebMD site states severe side effect that doesn't talk about the frequency with which that side effect occurs. That being said I know cankles aren't any fun to have. I am going to imagine that you have had chest pains or have an irregular or fast heart beat (tachycardia). This is why your physician put you on this particular combination. He is basically working within your body's homeostatic boundaries by alleviating the afterload on the heart (Norvasc) and decreasing the pumping pressure (atneolol). If you're having the fluid build up and your blood pressure remains ucontrolled you might consider a generic ACE or HCTZ. The data is stronger for chlorthalidone (another diuretic) but it is harder to monitor for your doctor. As far as being banned in Holland and Belgium, don't confuse ban with them preferring to use something else, in this case nitrendipine. The likely cause of this (like all other bad formulary decisions) is cost. In terms of bp control, side-effect profile, and convenience (1 each day vs. 2 each day) amlodipine wins hands down. Hope this helps, JK"

c_schumacker replied: "Atenolol is in a class of medications called a beta blocker. It has been around for nearly a half century. It has a very sound safety profile. It is a good medication for blood pressure especially if there is any risk for coronary disease. It also is a good medication if you are experiencing fast heart rates or arrhythmias like atrial fibrillation. I disagree that you would necessarily use this combination for chest pain but of course it would make logical sense since both of these medications can be used to allieviate angina. Amlor is the name Amlodipine (Norvasc) is sold in Belgium. Norvasc is in a class of medications called calcium channel blockers. There are a number of studies to support CCB as an appropriate choice for blood pressure control. It is the fourth-largest-selling drug in the world including sales in Belgium and Holland. Its success has been driven by its very good efficacy, once-daily dosing, consistent 24-hour control of hypertension and angina, and excellent historical safety record and tolerability. The product has been studied in more than 400,000 patients and has been used in more than 30 billion patient days of therapy worldwide. The one side effect that people can experience is fluid retention/swelling - which often shows up at the ankles - if it does at all."

Has anyone ever taken High Blood Pressure while pregnant? I developed chronic hypertension about 2 years ago. I'll be conceiving soon and my doc has me on Aldomet (Methyldopa) 250 mg. 3 x's a day and Norvasc (Amlodipine) 10 mg. daily. Has any of you ever taken these meds the entire pregnancy. Please let me know. Thanks

Bridget replied: "I was on Aldomet throughout my last pregnancy, along with labetalol. I never took Norvasc, but the other 2 were completely safe. Norvasc is a pregnancy category C, by the way. A and B categories are relatively safe, C is a bit more risky."

sabrinaelder replied: "Of course, we all have take a blood pressure while pregnancy. If you had a high blood pressure. Your doctor will give you a medicine to reduce your blood pressure. And tell your doctor that you have medicine that you had been taking. They'll look into. Could be cause you had a high blood pressure, when you had been taking a medicine."

Is Amlodipine goood medicine for hight blood pressure ? Is Amlodipine goood medicine for hight blood pressure ? is it a first line drug ? is it for long term treatment ? is it safe and less side effect from another medicine ? does it give for young age with high blood presssure ? has anyone take amlodpine ? i am 30 years old , i am taking amlidipine 5 mg and lisinopril 10 mg for 2 months blood pressure now 130/66

icustat replied: "The typical hiarchy for blood pressure medications are: 1) diuretics 2) ace inhibitors (like your lisinopril) 3) angiotensin blockers 4) beta blockers (atenolol) 5) calcium channel blockers (like amlodipine) As far as overall safety goes, calcium channel blockers are 5th on the list, you may want to ask why they didn't raise your lisinopril or add a beta blocker. The problem with calcium channel blockers is that they may make you weaker (strengthwise) and they are very difficult to come off of, and dangerous to miss a dose) So unless your high blood pressure is coupled with poor blood supply to your heart, it would not be my first choice or even my third."

Jimmy Changa replied: "Amlodipine is a very good blood pressure tablet, and is the most commonly prescribed antihypertensive in the world. Its benefits are that it has little in the way of side effects, although some people notice swelling of the ankles. It is complementary to your lisinopril. In most situations, blood pressure tablets are for life."

AH replied: "it's good as long as you don't have swelling in your legs as this could become exacerbated. That being said, it should not be used as first-line for hypertension unless there a contraindication to hctz."

Wendy M replied: "yes it is it is widely used as it has less side effects. tit can be used for longterm ans often used with another drug if it has not proven to be effective. how ever there are some natural stuff you can so to help you get off drugs completely. try this link "

can i sue sildenafil when i am using nifedipine? For BP i am using Telmisartan 40 mg, and amlodipine 5 mg. Recently my doctor added nifedipine 10 mg. For ED i am using Sildenfil 50 mg once in a week. Today i would like to use sildinafil. I got a doubt whether i take it along with the newly added nifedipine 10 mg. If any one is using please tell me. Thanks.

Mike K replied: "I would strongly recommend you have this discussion with your doctor. It sounds like you have uncontrolled hypertension, so anything that efects your pressure should be reviewed with a professional."

Harmony replied: "Sildinafil is not a good idea if you have uncontrolled hypertension. Please talk to your doctor before using."

mutantalbino replied: "Call your pharmacist. They would be glad to field your question and would know for sure."

blood pressure? been of work since 26 june for blood pressure taking simvastin 20mg bendroflumethiaze amlodipine 10 mg blood pressure still high i have to wait 30 minutes before i get blood pressure taken i find this stressful and get told come back in 1 or 2 weeks

truefrog2002 replied: "what is the question?"

sean replied: "I was also had the same problem, but start 5 years ago I said good bye to high blood pressure. Keep your life with easy way, control your food (vegetarian will be best), do enough exercise."

Avondrow replied: "Earlier this year I was in a similar situation, very high blood pressure and on almost the same mediaction. But I also changed my diet and took exercise. I'm much better now. Watch out for the simvastatin - that's to control cohlesterol, and can have nasty side effects if you are on it too long."

baling replied: "I am on same medication plus a couple more. I understand totally the tension while waiting... I used to be that way about it too. Think about what the blood pressure test is before you go in,lets face it theres only one person there and they are only going to put a small belt on your arm and pump it up for about 10 seconds then release the pressure....over and done...easy. No hardship at all....easy....sorted. Just keep telling youself this.....you.... will......be....ok. It took me five visits and three changes in medication till the doc found the correct medication.They start of with a medication then either add or subtract to it till they get it right.They have to do it that way in order to ensure that you get the correct medication because everyone reacts differently to medication..Better taking their time and ensuring that you get proper medication that suits you rather than you having an adverse effect. The docs are there to help us and help us they do... but because we do stress easily we sometimes wonder if they are doing the right things. You must trust the docs they do know what they are doing. Being overweight and smoking are big factors in high blood pressure..I am both..smoking thickens the blood therebye increasing blood pressure....I havent manage to stop yet.....but I am getting my weight under control .....slowly but surely......I am excercising a bit more now. Stick with it and find ways to keep yourself calm in your mind.....I started medidation (which I used to think was a load of cr*p but find that it really keeps me calm. Enjoy life it really is a wonderful thing. I will be thinking about you lots...very good luck to you."

chukaineO replied: "i have the same problem too and actually i found it very difficult to change my lifestyle because of the kind of jobb that i have but i still really want to change it, i think its better to loose some weight and excercise more,afterall the cost of the medicines are far greater than the cost of entering training club.try harder and good luck"

steve b replied: "They will get the correct medication and dose in due course, which is why, in the early stages of diagnosis, they ask you back regularly for check-ups."

hi there ? i have questions? Currently Ezetimibe with attorvastatin is used to control LDL in particular and l Currently Ezetimibe with attorvastatin is used to control LDL in particular and lipids in general. In my case, My Lp(a)is 55 while lipid range is normal. Is it necessary to add Ezetimibe to statin for Lp(a) in the drug regimen ? 2. Diruitic like Indapamide 1.5 SR or HCTZ 12.5 is contraindicated in person having high uric acid levels without gouty manifestations and on allopurinol 300 ? 4. What are the pssible options for me who is on amlodipine 10 mg Losartan 100 and Atenolol-100. Doctor wants me to delete Amlodipine because of pedal edema- Mild incompetent sapheno femoral junction. If Amlodipine is deleted, what are other options ? Does combinations of Ramipril 10 + Losartan 100 + Atenolol 100 take care of amlodipine ? I am male 50 hypertensive with obesity 105 kg. Non diabetic non smoker non alcoholic stricy vegitarian. Please guide. 5. Is Nicotinic Acid or Fenofibrate helpful in increasing HDL.? I am a brisk walker but unable to increase my HDL. I shall be obliged to receive your gu

Yvette C replied: "Omega 3 fish oil supplements Almonds Fish OATMEAL for breakfast everyday These are all things you can do to help lower your cholesterol levels. Of course, you need to cut fat out of your diet. It is a lifestyle change. Good luck."

How can i make the peak for amlodipine appear using HPLC? How can i make the peak for amlodipine appear using HPLC? i'm still new in HPLC. I'm trying to analyze amlodipine at the concentrations of 100 ng/ml to 1000 ng/ml (100 ng/ml, 250, 500 and 1000). here are some additional information bout the HPLC that i'm using: column: 46-150 mm wavelength is set at 240 - 362 running time: 1 hour mobile phase: ACN + KH2PO4 (37:43 V/V) i've tried using 10 mg/ml and the peak appeared at 6.34 mins but i can't get it to appear at other concentrations that i've mentioned above. Can somebody help me pls? here's some more details that i've forgotten to put. injection volume is 100 µL column is C18 i've tried diluting the Amlodipine from the stock solution (1mg/ml) using mobile phase and the peak does appear. But when i tried using MeOH...there was no peak except for the solvent peak. the pH of the buffer is 3.5

apoorapothecary replied: "Okay - there's some key details missing in your question. You look to have a buffer set up - what pH are you at? The column - is it a C18? Column temperature? What instrument are you using? All the details are pretty important if you want to improve the chromatography. If you're getting a consistent peak for 10mg/ml, here's what I think you might do to possibly improve your results. Wavelength - you have a range listed - are you capturing with diode array? If its a single-wavelength, you should likely have the wavelength setting at 360 - 366, roughly where the max is. If its a Agilent/DAD system, run a minimum of a 8nm bandwidth, turn off the reference bandwidth, and have the slit set to at least 4. Keep the defaults for most of the rest. Injection volume - you should be injecting at least 10µL - you can probably go up to 50µL without a peak distortion problem, if your diluent is close to the mobile strength. Most importantly - CHANGE ONE THING AT A TIME! Don't make the mistake of rushing things through, particularly as a newb to HPLC. You want to learn the nuances of chromatography, and what effect changes to the system have on performance. Make those changes in bulk, and you'll never know for sure what you did to develop your chromatography. I know of people who have been in the industry for years who still "shotgun develop" the method, and they're always in the dark as to the best ways to efficiently develop a high-quality method. Good luck! Okay, given your additional information, 100µl injection using methanol as a diluent may be adversely affecting your separation. With a 4.6 column, you shouldn't be injecting more than 50µl (give or take given analyte mass), and even there, you should be approximating the initial mobile phase conditions (you can omit the buffer - that's okay). Compare your void volume peaks between the one injected in mobile phase and the one in methanol, and one of a methanol blank alone for evidence of the peak washing out in your void. Did you check to see if your sample can dissolve in an acetonitrile:water mix approximating your initial conditions? Also, I forgot - when I'm running above 350nm, I make sure both UV and vis lights are on on my detector, just to be sure, since visible starts around 380, it couldn't hurt!"

Merlin's Feline replied: "Based on the data I could find...most HPLC analyses of amlodipine use dynamic ranges of 1 to 90 micrograms /mL and a wavelength of 254 nm. I suspect that the molar absorptivity is around 20,000 M^-1cm^-1 which means that an absorbance of 0.05 would be equivalent to about 2.5 X 10^-6 M = 2.5 micromolar = ~ 1.02 ug/mL Try usng the above dynamic range for your standards and adjusting the sensitivity of your UV detector to 0.1 AUFS ad maybe even 0.05 AUFS if the baseline is fairly flat and you will have a better S/N ratio"

medicine question ? I am 38 years old , healthy guy i only have high blood pressure i am taking two medicine lisinopril 10 mg and amlodipine 5 mg and my blood pressure before medicine was 175/95 and now in doctor office 110/62 . all my blood tests normal my question is does amlodipine lower cholestrol level ,uric acid that coz gout and glouces or its increase ? is the both medicine safe? doctor said lisiopirl isvery good medicine and its protect ur kidney and hope to find a good answer from educated people 10 points for best answer

TONY C replied: "You're in good shape..Stay on them. Neither lowers cholesterol or uric acid and both are quite safe."

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